Could someone explain to me how Focus items and Artifacts and Scrolls for that matter work. I know if you put them in your off-hand and you are using a one-handed weapon they appear to function. So if you always use two-handed weapons does that mean you can never use any of these items? Are scrolls supposed to be single use permanent change items, or are they multi-use temporary change items?
Scrolls, Icons, and Artifacts all work the same way. you just hold them in your other hand and make sure you meet the requirement. (You might be confusing scrolls with runes.)
And, yes, if you use 2-handed weapons, you cannot benefit from icons and such.